
Pycnogenol®, a patented, proprietary extract made exclusively from French maritime
pine bark (Pinus pinaster, manufactured by Horphag Research, Geneva, Switzerland). Pycnogenol extract is standardized to contain 70 ± 5% procyanidins in compliance with USP 28, compounds known for relatively significant antioxidant and anti-inflammatory activity, among other actions. Pycnogenol was ranked among the top 30 selling herbal dietary supplements in the United States in mainstream retail outlets (food, drug, and mass market stores) in 2008 in terms of dollar sales and had a total sales increase of nearly 34% over the previous year.
Dosage and Duration of Ad ministration
The following doses were used in the clinical trials reported in the
table in the full monograph. [Note: Some of the doses are based on
single studies or uncontrolled studies.]
ADHD: 1 mg/kg of body weight/day
Asthma: 1 mg/lb of body weight/day
Cholesterol/dyslipidemia: 120-150 mg/day
Chronic Venous Insufficiency: 150-360 mg/day
Diabetes: 50-200 mg/day
Dysmenorrhea: 30-60 mg/day
Endometriosis: 60 mg/day
Erectile dysfunction: 120 mg/day
Hypertension: 100-200 mg/day
Melasma: 75 mg/day
Muscle cramps: 200 mg/day
Osteoarthritis: 100-150 mg/day
Perimenopause: 200 mg/day
Platelet function: 25-200 mg/day
Retinopathy: 20-160 mg/day